International Symposium on Current Progress in Functional Materials | |
The synthesis of 2-(5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol using sodium impregnated on activated chicken eggshells catalyst | |
Mardiana, L.^1 ; Bakri, R.^1 ; Septiarti, A.^1 ; Ardiansah, B.^1 | |
Department of Chemistry, Faculty of Mathematics, Natural Sciences Universitas Indonesia, Kampus UI Depok, Depok | |
16424, Indonesia^1 | |
关键词: 2-hydroxyacetophenone; Aldol condensation; Anti-oxidant activities; FTIR spectrophotometers; Hydrazine hydrate; Pyrazoline derivative; Structure elucidation; Wet impregnation; | |
Others : https://iopscience.iop.org/article/10.1088/1757-899X/188/1/012022/pdf DOI : 10.1088/1757-899X/188/1/012022 |
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来源: IOP | |
【 摘 要 】
The novel compound of 2-(5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol as a pyrazoline derivative has been synthesized by two-steps reaction using sodium impregnated on activated chicken eggshells (Na-ACE) catalyst. Na-ACE was primarily prepared by a simple wet impregnation of NaOH solution on activated chicken eggshells solid support. The Na-ACE catalyst produced was characterized using FTIR spectrophotometer, XRD and SEM then applied in pyrazoline synthesis. First, chalcone was prepared from the reaction of 2-hydroxyacetophenone and 3-methoxybenzaldehyde by base-catalyzed aldol condensation. This product was subsequently reacted with hydrazine hydrate to give corresponding pyrazoline. The structure elucidation of the compound using FTIR, UV-Vis, LC-ESI-MS and1H-NMR indicated the desired product has been successfully synthesized. Furthermore, the potential antioxidant activities of chalcone and pyrazoline have also been studied in-vitro using DPPH radical scavenging method. The results revealed that pyrazoline has a greater antioxidant activity than chalcone.
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The synthesis of 2-(5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol using sodium impregnated on activated chicken eggshells catalyst | 1997KB | download |