The synthesis of 2-(5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol using sodium impregnated on activated chicken eggshells catalyst

International Symposium on Current Progress in Functional Materials

Mardiana, L.^1 ; Bakri, R.^1 ; Septiarti, A.^1 ; Ardiansah, B.^1

Department of Chemistry, Faculty of Mathematics, Natural Sciences Universitas Indonesia, Kampus UI Depok, Depok

16424, Indonesia^1

关键词: 2-hydroxyacetophenone;    Aldol condensation;    Anti-oxidant activities;    FTIR spectrophotometers;    Hydrazine hydrate;    Pyrazoline derivative;    Structure elucidation;    Wet impregnation;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/188/1/012022/pdf
DOI  :  10.1088/1757-899X/188/1/012022

来源: IOP

【 摘 要 】

The novel compound of 2-(5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol as a pyrazoline derivative has been synthesized by two-steps reaction using sodium impregnated on activated chicken eggshells (Na-ACE) catalyst. Na-ACE was primarily prepared by a simple wet impregnation of NaOH solution on activated chicken eggshells solid support. The Na-ACE catalyst produced was characterized using FTIR spectrophotometer, XRD and SEM then applied in pyrazoline synthesis. First, chalcone was prepared from the reaction of 2-hydroxyacetophenone and 3-methoxybenzaldehyde by base-catalyzed aldol condensation. This product was subsequently reacted with hydrazine hydrate to give corresponding pyrazoline. The structure elucidation of the compound using FTIR, UV-Vis, LC-ESI-MS and1H-NMR indicated the desired product has been successfully synthesized. Furthermore, the potential antioxidant activities of chalcone and pyrazoline have also been studied in-vitro using DPPH radical scavenging method. The results revealed that pyrazoline has a greater antioxidant activity than chalcone.