Polymorphic Forms of Furosemide Characterized by THz Time Domain Spectroscopy

Bulletin of the Korean chemical society

Min Ge¹  Wenfeng Wang¹  Guifeng Liu¹  Shihua Ma¹ 

关键词: Terahertz;    Furosemide;    DFT;    XRPD;    Polymorphic forms;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Terahertz time domain spectroscopy (THz-TDS) is applied in transmission to identify the five forms of modifications of furosemide and one commercial product from 0.3 THz to 1.6 THz at room temperature. The different absorption spectra of the different forms are sensitive to crystal structures. Density function theory (DFT) calculation was used to understand the vibrational modes of furosemide in the THz region. X-ray powder diffractometry (XRPD) was applied to confirm the different forms of modifications. The results demonstrate that THz-TDS is a potential analytical technique in investigating polymorphic forms in the pharmaceutical fields.

【 授权许可】

Unknown