Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using HClO4-SiO2as a Heterogeneous and Recyclable Catalyst

Bulletin of the Korean chemical society

Jung Yun Do¹  Ketack Kim¹  Muchchintala Maheswara¹  Sang Hyun Oh¹ 

关键词: Dihydropyrimidinones;    Dihydropyrimidinthiones;    HClO4-SiO2;    Silica-supported catalyst;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported perchloric acid (HClO₄-SiO₂) as a heterogeneous catalyst from an aldehyde, �?-dicarbonyl compound, and urea or thiourea under solvent-free conditions. Compared to the classical Biginelli reactions, this method consistently has the advantage of high yields, short reaction time, easy separation, and tolerance towards various functional groups.

【 授权许可】

Unknown