Synthesis of New dihydropyrimidinones catalysed by dicationic ionic liquid

Journal of Chemical Sciences

Aparna A Mulay¹  Ramrao A Mane1¹  Jyotirling R Mali¹  Umesh R Pratap¹  Dhanaji V Jawale¹ 

[1] Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India$$

关键词: Dihydropyrimidinones;    quinoline;    dicationic ionic liquid;    ethereal linkage;    Biginelli reaction.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]-1H-imidazolium dibromide (C3 [min]2 2 [Br−] )). Simple work-up procedures and moderate to good yields of the pyrimidinones and the intermediates are the merits of the route.

【 授权许可】

Unknown