Hydroxylated Hydrocinnamides as Hypocholesterolemic Agents

Bulletin of the Korean chemical society

Eungsoo Kim¹  Chul-Ho Lee¹  Sang-Hun Jung¹  Sangku Lee¹  Hyeong Kyu Lee¹ 

关键词: Cinnamic acid;    Hydrocinnamide;    Amino acid;    Hypocholesterolemic activity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowering activities and the number of free phenolic hydroxy groups affect greatly the activities. 3,4-Dihydroxy hydrocinnamides obtained from amino acid derivatives containing a hydrophobic side chain such as alanine, valine, phenylalanine, and isoleucine exhibited potent cholesterol-lowering activities.

【 授权许可】

Unknown