Antiprotozoal action of synthetic cinnamic acid analogs

Sociedade Brasileira de Medicina Tropical. Revista

Medeiros, Daniel Sol Sol de¹  Santos, Ana Paula de Azevedo dos²  Fialho, Saara Nery³ 

[1] Centro Universitário São Lucas, Porto Velho, Brasil;Fundação Oswaldo Cruz, Porto Velho, Brazil;Universidade Federal de Rondônia, Porto Velho, Brazil

关键词: Bioactivity;    Cinnamic acid;    Leishmaniasis;    Synthetic.;   

DOI  :  10.1590/0037-8682-0499-2017

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTIONLeishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds.METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined.RESULTSThree analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed.CONCLUSIONSAntiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.

【 授权许可】

CC BY