Synthesis and Characterization of Degradable Polycationic Polymers as Gene Delivery Carriers

Bulletin of the Korean chemical society

Jong-sang Park¹  Jae Keun Yoon¹  Joon Sig Choi¹  Kwan Kim¹  Bo Hye Kim¹  Min Sung Kwon¹  Hyun Jin Kim¹ 

关键词: Gene therapy;    Gene delivery;    Biodegradable polymer;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Biodegradable cationic poly(ester-amide) polymers were synthesized by double-monomer method, that showed excellent solubility in many organic solvents and water. Different degradation patterns were obtained by the regulation of monomer ratios and overall long period of time of DNA protection up to 12 days was shown by PicoGreen reagent assay. Good transfection profiles in the presence of serum and very low toxicity on mammalian cells may allow these polymers to become suitable for long-term gene delivery systems and therapeutic applications.

【 授权许可】

Unknown