Estimation for Retention Factor of Isoflavones in Physico-Chemical Properties

Bulletin of the Korean chemical society

Seung Ki Lee¹  Kyung Ho Row¹ 

关键词: Physico-chemical properties;    Retention factors;    Correlation relationships;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The estimation of retention factors by correlation equations with physico-chmical properties maybe helpful in chromatographic work. The physico-chemical properties were water solubility (S), hydrophobicity (P), total energy (Et), connectivity index 1 (1 �?), hydrophilic-lipophlic balance (x) and hydrophilic surface area (h) of isoflavones. The retention factors were experimentally measured by RP-HPLC. Especially, the empirical regulations of water solubility and hydrophobicity were expressed in a linear form. The equation between retention factors and various physico-chemical properties of isoflavones was suggested as k = a0 + a1log S + a2log PQ + a3 (Et) + a4 (1 �?) + a5 (x) + a6 (h), and the correlation coefficients estimated were relatively higher than 0.95. The empirical equations might be successfully used for a prediction of the various chromatographic characteristics of substances, with a similar chemical structure.

【 授权许可】

Unknown