Synthesis and characterization of core�?�shell magnetic molecularly imprinted polymer nanoparticles for selective extraction of tizanidine in human plasma

Bulletin of materials science

SALAH KHANAHMADZADEH²  MOAYAD HOSSAINI SADR¹  GOLALEH SHEYKHAGHAEI¹ 

[1] Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 1477893800, Iran$$Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 1477893800, IranDepartment of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 1477893800, Iran$$;Department of Chemistry, Mahabad Branch, Islamic Azad University, Mahabad 5913933137, Iran$$Department of Chemistry, Mahabad Branch, Islamic Azad University, Mahabad 5913933137, IranDepartment of Chemistry, Mahabad Branch, Islamic Azad University, Mahabad 5913933137, Iran$$

关键词: Magnetic nanoparticles;    molecularly imprinted polymers;    tizanidine;    paracetamol;    human plasma.;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

In this study, simple, effective and general processes were used for the synthesis of a new nanomolecularly imprinted polymers (MIPs) layer on magnetic Fe3O4 nanoparticles (NPs) with uniform core�?�shell structure by combining surface imprinting and nanotechniques. The first step for the synthesis of magnetic NPs was co-precipitation of Fe$^{2+}$ and Fe$^{3+}$ in an ammonia solution. Then, an SiO$_2$ shell was coated on the magnetic core with the Stöber method. Subsequently, the C$=$C groups were grafted onto the silica-modified Fe$_3$O$_4$ surface by 3-(trimethoxysilyl) propyl methacrylate. Finally, MIPs films were formed on the surface of Fe$_3$O$_4$@SiO$_2$ by the copolymerization of C$=$C end groups with methacrylic acid (functional monomer), ethylene glycol dimethacrylate (crosslinker),2,2-azobisisobutyronitrile (initiator) and tizanidine (template molecule). The products were characterized using techniques that included Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), UV spectrophotometry, transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). Measurement of tizanidine through use of the core�?�shell magnetic molecularly imprinted polymers nanoparticles (MMIPs-NPs) in human plasma samples compared to the paracetamol showed that the synthesized nanosized MMIP for tizanidine has acted selectively.

【 授权许可】

Unknown