Nanohydroxyapatite synthesis using optimized process parameters for load-bearing implant

Bulletin of materials science

Feven Mattews Michael⁴  M E Hoque¹  M Khalid⁴  C T Ratnam³  Mohammad Reza Ketabchi⁴  W Rashmi² 

[1] Department of Biomedical Engineering, King Faisal University Al-Hofuf, Al-Ahsa 31982, Kingdom of Saudi Arabia$$Department of Biomedical Engineering, King Faisal University Al-Hofuf, Al-Ahsa 31982, Kingdom of Saudi ArabiaDepartment of Biomedical Engineering, King Faisal University Al-Hofuf, Al-Ahsa 31982, Kingdom of Saudi Arabia$$;Energy Research Group, School of Engineering, Taylor’s University, 47500 Subang Jaya, Selangor, Malaysia$$Energy Research Group, School of Engineering, Taylor’s University, 47500 Subang Jaya, Selangor, MalaysiaEnergy Research Group, School of Engineering, Taylor’s University, 47500 Subang Jaya, Selangor, Malaysia$$;Radiation Processing Technology Division, Malaysian Nuclear Agency, Bangi, Selangor, Malaysia$$Radiation Processing Technology Division, Malaysian Nuclear Agency, Bangi, Selangor, MalaysiaRadiation Processing Technology Division, Malaysian Nuclear Agency, Bangi, Selangor, Malaysia$$;Division of Manufacturing and Industrial Processes, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia$$Division of Manufacturing and Industrial Processes, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, MalaysiaDivision of Manufacturing and Industrial Processes, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia$$

关键词: Nanohydroxyapatite;    ultrasonication;    response surface methodology;    calcination;    optimization.;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

In this study, nanohydroxyapatite (NHA) was synthesized using calcium nitrate tetrahydrate and diammonium hydrogen phosphate via the precipitation method assisted with ultrasonication. Three independent process parameters: temperature (�??) (70, 80 and 90°C), ultrasonication time (�?) (20, 25 and 30 min), and amplitude (𝐴) (60, 65 and 70%) were studied and optimized using response surface methodology based on 3 factors and 5 level central composite design. The responses of the model were analysed with the help of the particle size measured from field-emission scanning electron microscopy and Brunauer�?�Emmett�?�Teller (BET). The surface area of particle was measured with BET and the thermal stability of the powder was measured using thermogravimetric analysis. Finally, with the optimized process parameters obtained from the model, the NHA powder was synthesised and validated against the predicted value. The results show a good agreement with an average error 8% between the actual and predicted values. Moreover, the thermal stability and porosity of synthesized NHA was further improved after calcination. This improvement could be due to the removal of impurities from the NHA powder after calcination as indicated by the Fourier transform infrared spectroscopy and energy-dispersive X-ray spectroscopy.

【 授权许可】

Unknown