Formulation and Evaluation of Clotrimazole Niosomal Gel for Topical Application

RGUHS Journal of Pharmaceutical Sciences

Ganesh G Keshavshett³  Sidramappa B Shirsand¹  Padivala V Swamy¹  Gara Rathan Kumar²  Sharanabasappa S Bushetti¹ 

[1] Department of Pharmaceutical Technology, HKES’s College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, INDIADepartment of Pharmaceutical Technology, HKES’s College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, INDIADepartment of Pharmaceutical Technology, HKES’s College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, INDIA;Department of Pharmaceutical Technology, HKES’s College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, INDIADepartment of Pharmaceutical Technology, HKES’s College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, INDIADepartment of Pharmaceutical Technology, HKES’s College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, INDIA;Department of Pharmaceutics, S.V.E.T.’s College of Pharmacy, Kallur Road, Humnabad-585330, Karnataka, INDIADepartment of Pharmaceutics, S.V.E.T.’s College of Pharmacy, Kallur Road, Humnabad-585330, Karnataka, INDIADepartment of Pharmaceutics, S.V.E.T.’s College of Pharmacy, Kallur Road, Humnabad-585330, Karnataka, INDIA

关键词: Carbopol gel;    Clotrimazole;    Cholesterol;    Niosome;    Span-40;    Thin hydration film.;   

DOI  :  10.5530/rjps.2015.1.4

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

Objective: In the present investigation, an attempt is made to develop and characterize niosomal gel formulation of clotrimazole to increase retention time in the dermis layer through controlled release of the drug. Methodology: Clotrimazole niosomes were prepared by thin film hydration method using span 40 (as non-ionic surfactant) and cholesterol (as stable vesicle forming agent). The niosomal dispersion was evaluated for vesicle size, surface morphology, percent entrapment efficiency and in vitro drug release. Results: Among the five formulations prepared, the formulation CN3 (containing 100 mg drug, 200 mg surfactant) was found to be promising. Selected niosomal suspension (CN3) containing clotrimazole equivalent to 2 % w/w was incorporated into gel base composed of carbopol (1%), triethanolamine 0.3% and distilled water quantity sufficient. The gel was studied for it’s different parameters such as pH, in vitro drug release, anti-fungal activity and skin irritation effect. Conclusion: The studies suggest that encapsulating clotrimazole in nonionic surfactant vesicles would provide better patient compliance by achieving prolonged release of the drug to the dermis with improved efficacy.

【 授权许可】

Unknown