Antiurolithiatic Activity of Crashcal on Ethylene Glycol Induced Urolithiasis in Rats

RGUHS Journal of Pharmaceutical Sciences

A.H.M Vishwanathswamy¹  B.C Koti¹  P. Dixit¹ 

[1] Department of Pharmacology, K.L.E. University’s College of Pharmacy, Hubli–580031, Karnataka, India.Department of Pharmacology, K.L.E. University’s College of Pharmacy, Hubli–580031, Karnataka, India.Department of Pharmacology, K.L.E. University’s College of Pharmacy, Hubli–580031, Karnataka, India.

关键词: Crashcal;    calculi;    antiurolithiatic;    antioxidant activity.;   

DOI  :  10.5530/rjps.2014.1.6

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

The present study was designed to evaluate effect of Crashcal, a polyherbal formulation in the treatment of renal calculi. The urolithiasis was induced by ethylene glycol. Male Wistar rats (150–200 g) were selected and divided into seven groups. Ethylene glycol (0.75%) in drinking water was fed to all groups except normal group (Group–1) till 28th day to induce calculi. Group–4 and Group–5 served as preventive regimen (PR) and Group–6 and Group–7 served as curative regimen (CR) and were treated with different doses of Crashcal. Group–1, 2 and 3 served as normal,calculi induced and standard (cystone 750 mg/kg) respectively. Oxalate, calcium and phosphates were monitored in the urine and kidney. Serum BUN, creatinine and uric acid were also recorded. In-vivo antioxidant parameters such as lipid peroxidation (MDA), glutathione (GSH) and superoxide dismutase (SOD), catalase (CAT), body weight, kidney weight and urine volume were also monitored. In hypercalculi animals, the oxalate, calcium and phosphate excretion grossly increased. However, the increased deposition of stone forming constituents was significantly lowered by Crashcal. It was also observed that Crashcal produced significant decrease in MDA and increased GSH, SOD and CAT. The present study suggests that Crashcal possess significant antiurolithiatic and antioxidant activity in rats.

【 授权许可】

Unknown