Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern

Journal of Gastrointestinal Oncology

Manal M. Hassan⁷  Aziz Tabash⁷  Benjamin R. Kipp²  Amr S. Soliman¹  Ahmed O. S. Abousamra⁷  Jeremy Jones³  Yazan Fahmawi⁷  Lianchun Xiao⁷  Robert R. McWilliams³  Humaid O. Al-Shamsi⁵  Reham Abdel-Wahab⁶  Robert A. Wolff⁷  Ibrahim Dahbour⁷  Kenna R. Shaw⁴  Scott Kopetz⁷ 

[1] Department of Epidemiology, the University of Nebraska Medical Center, Omaha, Nebraska, USADepartment of Epidemiology, the University of Nebraska Medical Center, Omaha, Nebraska, USADepartment of Epidemiology, the University of Nebraska Medical Center, Omaha, Nebraska, USA;Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA;Department of Oncology, Mayo Clinic, Rochester, Minnesota, USADepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USADepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA;Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USASheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USASheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA;Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAKhalifa Bin Zayed Al Nahyan Foundation, Abu Dhabi, United Arab EmiratesSheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAKhalifa Bin Zayed Al Nahyan Foundation, Abu Dhabi, United Arab EmiratesSheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAKhalifa Bin Zayed Al Nahyan Foundation, Abu Dhabi, United Arab EmiratesDepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAKhalifa Bin Zayed Al Nahyan Foundation, Abu Dhabi, United Arab EmiratesSheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USASheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAKhalifa Bin Zayed Al Nahyan Foundation, Abu Dhabi, United Arab EmiratesSheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA;Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAClinical Oncology Department, Assiut University, Assiut, EgyptDepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAClinical Oncology Department, Assiut University, Assiut, EgyptClinical Oncology Department, Assiut University, Assiut, EgyptDepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USAClinical Oncology Department, Assiut University, Assiut, Egypt;Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA

关键词: Somatic mutations;    colorectal cancer (CRC);    next-generation sequencing (NGS);    Arab population;   

DOI  :  10.21037/jgo.2016.11.02

学科分类：肿瘤学

来源: Pioneer Bioscience Publishing Company

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