Exploration of the Genetic Organization of Morphological Modularity on the Mouse Mandible Using a Set of Interspecific Recombinant Congenic Strains Between C57BL/6 and Mice of the Mus spretus Species

G3: Genes, Genomes, Genetics

Gaëtan Burgio³  Evelyne Heyer¹  Xavier Montagutelli⁴  Michel Baylac² 

[1] Unité d’éco-anthropologie, équipe « génétique des populations humaines », CNRS MNHN, P7, UMR 7206, CP 139, 75231 Paris, FranceUnité d’éco-anthropologie, équipe « génétique des populations humaines », CNRS MNHN, P7, UMR 7206, CP 139, 75231 Paris, FranceUnité d’éco-anthropologie, équipe « génétique des populations humaines », CNRS MNHN, P7, UMR 7206, CP 139, 75231 Paris, France;Origine, structure et évolution de la biodiversité, UMR 7205 and Plate-forme de Morphométrie, MNHN, CNRS-MNHN, UMS 2700, CP 50, Muséum National d’Histoire Naturelle, 75005 Paris, FranceOrigine, structure et évolution de la biodiversité, UMR 7205 and Plate-forme de Morphométrie, MNHN, CNRS-MNHN, UMS 2700, CP 50, Muséum National d’Histoire Naturelle, 75005 Paris, FranceOrigine, structure et évolution de la biodiversité, UMR 7205 and Plate-forme de Morphométrie, MNHN, CNRS-MNHN, UMS 2700, CP 50, Muséum National d’Histoire Naturelle, 75005 Paris, France;Australian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales 2019, AustraliAustralian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales 2019, AustraliAustralian School of Advanced Medicine, Macquarie University, North Ryde, New South Wales 2019, Australi;Unité postulante de Génétique fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 75724 Paris, FranceUnité postulante de Génétique fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 75724 Paris, FranceUnité postulante de Génétique fonctionnelle de la Souris, CNRS URA 2578, Institut Pasteur, 75724 Paris, France

关键词: quantitative trait loci;    procrustes superimposition;    modularity;    morphological integration;    mouse genetics;    geometric morphometrics;   

DOI  :  10.1534/g3.112.003285

学科分类：生物科学（综合）

来源: Genetics Society of America

【 摘 要 】

Morphological integration and modularity within semi-autonomous modules are essential mechanisms for the evolution of morphological traits. However, the genetic makeup responsible for the control of variational modularity is still relatively unknown. In our study, we tested the hypothesis that the genetic variation for mandible shape clustered into two morphogenetic components: the alveolar group and the ascending ramus. We used the mouse as a model system to investigate genetics determinants of mandible shape. To do this, we used a combination of geometric morphometric tools and a set of 18 interspecific recombinant congenic strains (IRCS) derived from the distantly related species, Mus spretus SEG/Pas and Mus musculus C57BL/6. Quantitative trait loci (QTL) analysis comparing mandible morphometry between the C57BL/6 and the IRCSs identified 42 putative SEG/Pas segments responsible for the genetic variation. The magnitude of the QTL effects was dependent on the proportion of SEG/Pas genome inherited. Using a multivariate correlation coefficient adapted for modularity assessment and a two-block partial least squares analysis to explore the morphological integration, we found that these QTL clustered into two well-integrated morphogenetic groups, corresponding to the ascending ramus and the alveolar region. Together, these results provide evidence that the mouse mandible is subjected to genetic coordination in a modular manner.

【 授权许可】

Unknown