Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus

G3: Genes, Genomes, Genetics

Leo W. Buss³  Fadi G. Lakkis¹  Stephen L. Dellaporta⁴  Andrea Gloria-Soria²  Maria Moreno⁴  Anahid E. Powell² 

[1] Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15261Department of SurgeryDepartment of ImmunologyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15261Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15261Department of SurgeryDepartment of ImmunologyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261Department of SurgeryThomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15261Department of SurgeryDepartment of ImmunologyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261Department of ImmunologyThomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15261Department of SurgeryDepartment of ImmunologyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261Thomas E. Starzl Transplantation Institute, Pittsburgh, Pennsylvania 15261Department of SurgeryDepartment of ImmunologyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261;Department of Ecology and Evolutionary BiologyDepartment of Ecology and Evolutionary BiologyDepartment of Ecology and Evolutionary Biology;Department of Ecology and Evolutionary BiologyDepartment of Geology and Geophysics, Yale University, New Haven, Connecticut 06511Department of Ecology and Evolutionary BiologyDepartment of Ecology and Evolutionary BiologyDepartment of Geology and Geophysics, Yale University, New Haven, Connecticut 06511Department of Geology and Geophysics, Yale University, New Haven, Connecticut 06511Department of Ecology and Evolutionary BiologyDepartment of Geology and Geophysics, Yale University, New Haven, Connecticut 06511;Department of Molecular, Cellular, and Developmental BiologyDepartment of Molecular, Cellular, and Developmental BiologyDepartment of Molecular, Cellular, and Developmental Biology

关键词: hydroid;    cnidarian;    invertebrate immunity;    recognition;   

DOI  :  10.1534/g3.111.001149

学科分类：生物科学（综合）

来源: Genetics Society of America

【 摘 要 】

The Hydractinia allorecognition complex (ARC) was initially identified as a single chromosomal interval using inbred and congenic lines. The production of defined lines necessarily homogenizes genetic background and thus may be expected to obscure the effects of unlinked allorecognition loci should they exist. Here, we report the results of crosses in which inbred lines were out-crossed to wild-type animals in an attempt to identify dominant, codominant, or incompletely dominant modifiers of allorecognition. A claim for the existence of modifiers unlinked to ARC was rejected for three different genetic backgrounds. Estimates of the genetic map distance of ARC in two wild-type haplotypes differed markedly from one another and from that measured in congenic lines. These results suggest that additional allodeterminants exist in the Hydractinia ARC.

【 授权许可】

Unknown