Cortical Laminar Binding of PET Amyloid and Tau Tracers in Alzheimer Disease

Journal of Nuclear Medicine

Henry Rusinek¹  Shankar Vallabhajosula¹  Yukitsuka Kudo¹  Shozo Furumoto¹  Elizabeth Pirraglia¹  Ryuichi Harada¹  Lisa Mosconi¹  David Mozley¹  Wai Tsui¹  Mony J. de Leon¹  Hiroyuki Arai¹  Tracy Butler¹  Katsutoshi Furukawa¹  Nobuyuki Okamura¹  Yi Li¹ 

关键词: tau;    amyloid beta;    neocortical binding;    PET;   

DOI  :  10.2967/jnumed.114.149229

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter–white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon. Methods: Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the gray matter–white matter boundary. We studied 5 AD and 5 healthy subjects with both 18F-THK5117 (tau) and 11C-Pittsburgh compound B (Aβ) PET. Results: On average, tau-positive voxels were closer to the white matter than were Aβ-positive voxels. This effect was found for all AD subjects and for all regions, both before and after regionally adjusting for the nonspecific white matter binding of both tracers. The differential laminar pattern was validated through postmortem examination. Conclusion: Within cortical lamina, distance measures may be of value in testing PET tracers for their anatomic selectivity.

【 授权许可】

Unknown