Comparison of Simplified Parametric Methods for Visual Interpretation of 11C-Pittsburgh Compound-B PET Images

Journal of Nuclear Medicine

Pieter Raijmakers¹  Bart N.M. van Berckel¹  Philip Scheltens¹  Wiesje M. van der Flier¹  Human Adams¹  Rik Ossenkoppele¹  Albert D. Windhorst¹  Sofie M. Adriaanse¹  Marissa D. Zwan¹  Reina W. Kloet¹  Ronald Boellaard¹  Adriaan A. Lammertsma¹  Alexandra J.M. Beunders¹  Nelleke Tolboom¹ 

关键词: Alzheimer’s disease;    visual assessment;    positron emission tomography;    ¹¹C-PIB;   

DOI  :  10.2967/jnumed.114.139121

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

This study compared several parametric imaging methods to determine the optimal approach for visual assessment of parametric Pittsburgh compound-B (11C-PIB) PET images to detect cortical amyloid deposition in different memory clinic patient groups. Methods: Dynamic 11C-PIB scanning of 120 memory clinic patients was performed. Parametric nondisplaceable binding potential (BPND) images were compared with standardized uptake value (SUV) and SUV ratio images. Images were visually assessed by 3 independent readers, and both interreader and intermethod agreement was determined. Results: Both 90-min (Fleiss κ = 0.88) and 60-min (Fleiss κ = 0.89) BPND images showed excellent interreader agreement, whereas agreement was good to moderate for SUV ratio images (Fleiss κ = 0.68) and SUV images (Fleiss κ = 0.59). Intermethod agreement varied substantially between readers, although BPND images consistently showed the best performance. Conclusion: The use of BPND images provided the highest interreader and intermethod agreement and is therefore the method of choice for optimal visual interpretation of 11C-PIB PET scans.

【 授权许可】

Unknown