Influence of TSPO Genotype on 11C-PBR28 Standardized Uptake Values

Journal of Nuclear Medicine

Kwangsik Nho¹  Li Shen¹  Sungeun Kim¹  Karmen K. Yoder¹  Shannon L. Risacher¹  Andrew J. Saykin¹ 

关键词: ¹¹C-PBR28;    positron emission tomography;    TSPO;    genotype;   

DOI  :  10.2967/jnumed.112.118885

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

11C-PBR28 binds to the high-affinity state of the translocator protein 18 kDa (TSPO). A single-nucleotide polymorphism (rs6971) within the human TSPO gene determines the affinity state of the TSPO. The rs6971 genotype determines whether individuals express the high-, low-, or mixed-affinity phenotype of TSPO. The rs6971 genotype corresponds to in vivo 11C-PBR28 binding, as measured quantitatively by total volume of distribution. However, it is not known whether standardized uptake value (SUV) can detect differences in brain 11C-PBR28 uptake by TSPO genotype. Methods: Thirty-two older adults (71.8 ± 7.94 y old) underwent 11C-PBR28 PET scanning; rs6971 genotype was imputed after genomewide genotyping. SUV was extracted for several brain regions. The sample included 19 C/C carriers (high-affinity phenotype), 12 T/C carriers (mixed-affinity), and 1 T/T carrier (low-affinity) for rs6971. Results: SUV was 30% lower in T/C subjects than in C/C subjects. Conclusion: The results indicate that brain 11C-PBR28 SUV is sensitive to TSPO genotype.

【 授权许可】

Unknown