Journal of Nuclear Medicine | |
VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET | |
Rob Kreuger1  J. Peter H. Burbach1  Jan Booij1  Brendan Vastenhouw1  Marlies C. Goorden1  Freek J. Beekman1  Frans van der Have1  Carla F.M. Molthoff1  Ruud M. Ramakers1  | |
关键词: pinhole; SPECT; PET; small-animal; molecular imaging; neuroimaging; cardiac imaging; | |
DOI : 10.2967/jnumed.112.109538 | |
学科分类:医学(综合) | |
来源: Society of Nuclear Medicine | |
【 摘 要 】
Today, PET and SPECT tracers cannot be imaged simultaneously at high resolutions but require 2 separate imaging systems. This paper introduces a Versatile Emission Computed Tomography system (VECTor) for radionuclides that enables simultaneous submillimeter imaging of single-photon and positron-emitting radiolabeled molecules. Methods: γ-photons produced both by electron–positron annihilation and by single-photon emitters are projected onto the same detectors by means of a novel cylindric high-energy collimator containing 162 narrow pinholes that are grouped in clusters. This collimator is placed in an existing SPECT system (U-SPECT-II) with 3 large-field-of-view γ-detectors. From the acquired projections, PET and SPECT images are obtained using statistical image reconstruction that corrects for energy-dependent system blurring. Results: For PET tracers, the tomographic resolution obtained with a Jaszczak hot rod phantom was less than 0.8 mm, and 0.5-mm resolution images of SPECT tracers were acquired simultaneously. SPECT images were barely degraded by the simultaneous presence of a PET tracer, even when the activity concentration of the PET tracer exceeded that of the SPECT tracer by up to a factor of 2.5. Furthermore, we simultaneously acquired fully registered 3- and 4-dimensional multiple functional images from living mice that, in the past, could be obtained only sequentially. Conclusion: High-resolution complementary information about tissue function contained in SPECT and PET tracer distributions can now be obtained simultaneously using a fully integrated imaging device. These combined unique capabilities pave the way for new perspectives in imaging the biologic systems of rodents.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010198693ZK.pdf | 918KB | download |