Hepatic Blood Perfusion Measured by 3-Minute Dynamic 18F-FDG PET in Pigs

Journal of Nuclear Medicine

Ole Lajord Munk¹  Frank Viborg Mortensen¹  Michael Sørensen¹  Michael Winterdahl¹  Susanne Keiding¹ 

关键词: PET kinetics;    molecular imaging;    pharmacokinetics;    liver PET;    liver hemodynamics;   

DOI  :  10.2967/jnumed.111.088278

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

There is an unmet clinical need for an imaging method for quantification of hepatic blood perfusion. The purpose of the present study was to develop and validate a PET method using blood-to-cell clearance () of 18F-FDG, 3-O-11C-methylglucose (11C-MG), or 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) as a measure of hepatic blood perfusion without the need for portal venous blood samples. We aimed to make the method as simple as possible with the prospect of future application to clinical studies. For this purpose, we examined the possibility of using a 3-min data acquisition and a model-derived dual input calculated from measurements of radioactivity concentrations in a peripheral artery. Methods: Pigs (40 kg) underwent dynamic PET of the liver with 18F-FDG, 11C-MG, or 18F-FDGal with simultaneous measurements of time–activity curves in blood sampled from a femoral artery and the portal vein (PV); blood flow rates were measured in the hepatic artery (HA) and PV by transit-time flow meters. Two input functions were compared: A measured dual input and a model-derived dual input, the latter with the PV time–activity curve estimated from the measured arterial time–activity curve and a previously validated 1-parametric PV model.was estimated for each tracer by fitting compartmental models to the data, comparing 3-min and 60-min data acquisitions and the 2 dual-input time–activity curves. Results: Agreement betweenestimated using the measured and the model-derived dual input was good for all 3 tracers. For 18F-FDG and 11C-MG,(3-min data acquisition, model-derived dual input, and 1-tissue compartmental model) correlated to the measured blood perfusion (P = 0.01 and P = 0.07, respectively). For 18F-FDGal, the correlation was not significant. Conclusion: A simplified method for quantification of hepatic blood perfusion using 3-min dynamic 18F-FDG PET or 11C-MG PET with blood sampling from only a peripheral artery was developed. Parametricimages were constructed and showed homogeneous blood perfusion in these normal livers.

【 授权许可】

Unknown