Journal of Nuclear Medicine | |
Practical Approach for Comparative Analysis of Multilesion Molecular Imaging Using a Semiautomated Program for PET/CT | |
Mithat Gönen1  André Van Nuffel1  Heiko Schöder1  John L. Humm1  Somali Gavane1  Howard I. Scher1  Josef J. Fox1  Steven M. Larson1  Estelle Autran-Blanc1  Sadek Nehmeh1  Michael J. Morris1  | |
关键词: molecular imaging; PET/CT; 18F-FDG; 18F-FDHT; semi-automated; | |
DOI : 10.2967/jnumed.111.089326 | |
学科分类:医学(综合) | |
来源: Society of Nuclear Medicine | |
【 摘 要 】
We propose a standardized approach to quantitative molecular imaging (MI) in cancer patients with multiple lesions. Methods: Twenty patients with castration-resistant prostate cancer underwent 18F-FDG and 18F-16β-fluoro-5-dihydrotestosterone (18F-FDHT) PET/CT scans. Using a 5-point confidence scale, 2 readers interpreted coregistered scan sets on a workstation. Two hundred three sites per scan (specified in a lexicon) were reviewed. 18F-FDG–positive lesion bookmarks were propagated onto 18F-FDHT studies and then manually accepted or rejected. Discordance-positive 18F-FDHT lesions were similarly bookmarked. Lesional SUVmax was recorded. Tracer- and tissue-specific background correction factors were calculated via receiver-operating-characteristic analysis of 65 scan sets. Results: Readers agreed on more than 99% of 18F-FDG– and 18F-FDHT–negative sites. Positive-site agreement was 83% and 85%, respectively. Consensus-lesion maximum standardized uptake value (SUVmax) was highly reproducible (concordance correlation coefficient > 0.98). Receiver-operating-characteristic curves yielded 4 correction factors (SUVmax 1.8–2.6). A novel scatterplot (Larson-Fox-Gonen plot) depicted tumor burden and change in SUVmax for response assessments. Conclusion: Multilesion molecular imaging is optimized with a 5-step approach incorporating a confidence scale, site lexicon, semiautomated PET software, background correction, and Larson-Fox-Gonen graphing.
【 授权许可】
Unknown
【 预 览 】
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RO201912010197955ZK.pdf | 1145KB | download |