Folic Acid Conjugates for Nuclear Imaging of Folate Receptor–Positive Cancer

Journal of Nuclear Medicine

Roger Schibli¹  Cristina Müller¹ 

关键词: folic acid;    folate receptor;    SPECT;    PET;    cancer;   

DOI  :  10.2967/jnumed.110.076018

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates useful for SPECT and PET of cancer diseases. The potential applicability of folate radiopharmaceuticals for FR-targeted radionuclide therapy is also discussed.

【 授权许可】

Unknown