Tracing Cardiac Metabolism In Vivo: One Substrate at a Time

Journal of Nuclear Medicine

Heinrich Taegtmeyer¹ 

[1] Division of Cardiology, Department of Internal Medicine, the University of Texas Medical School at Houston, Houston, Texas Division of Cardiology, Department of Internal Medicine, the University of Texas Medical School at Houston, Houston, Texas Division of Cardiology, Department of Internal Medicine, the University of Texas Medical School at Houston, Houston, Texas

关键词: cardiology (basic/technical);    molecular imaging;    PET/MRI;    cardiac substrate imaging;    cardiac metabolic imaging;    cardiac structural imaging;   

DOI  :  10.2967/jnumed.109.068205

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

In the myocardial cell, a series of enzyme-catalyzed reactions results in the efficient transfer of chemical energy into mechanical energy. The goals of this article are to emphasize the ability of noninvasive imaging techniques using isotopic tracers to detect the metabolic footprints of heart disease and to propose that cardiac metabolic imaging is more than a useful adjunct to current myocardial perfusion imaging studies. A strength of metabolic imaging is in the assessment of regional myocardial differences in metabolic activity, probing for 1 substrate at a time. We hope that new and developing methods of cardiac imaging will lead to the earlier detection of heart disease and improve the management and quality of life for patients afflicted with ischemic and nonischemic heart muscle disorders.

【 授权许可】

Unknown