Kinetic Analysis of 18F-Fluoride PET Images of Breast Cancer Bone Metastases

Journal of Nuclear Medicine

Erin K. Schubert¹  David A. Mankoff¹  Julie R. Gralow¹  Mark Muzi¹  Jennifer M. Specht¹  Robert K. Doot¹  Lanell M. Peterson¹ 

关键词: PET;    ¹⁸F-fluoride;    radiotracer tissue kinetics;    bone metastases;    breast cancer;   

DOI  :  10.2967/jnumed.109.070052

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The most common site of metastasis for breast cancer is bone. Quantitative 18F-fluoride PET can estimate the kinetics of fluoride incorporation into bone as a measure of fluoride transport, bone formation, and turnover. The purpose of this analysis was to evaluate the accuracy and precision of 18F-fluoride model parameter estimates for characterizing regional kinetics in metastases and normal bone in breast cancer patients. Methods: Twenty metastatic breast cancer patients underwent dynamic 18F-fluoride PET. Mean activity concentrations were measured from serial blood samples and regions of interest placed over bone metastases, normal vertebrae, and cardiac blood pools. This study examined parameter identifiability, model sensitivity, error, and accuracy using parametric values from the patient cohort. Results: Representative time–activity curves and model parameter ranges were obtained from the patient cohort. Model behavior analyses of these data indicated 18F-fluoride transport and flux (K1 and Ki, respectively) into metastatic and normal osseous tissue could be independently estimated with a reasonable bias of 9% or less and reasonable precision (coefficients of variation ≤ 16%). Average 18F-fluoride transport and flux into metastases from 20 patients (K1 = 0.17 ± 0.08 mL·cm−3·min−1 and Ki = 0.10 ± 0.05 mL·cm−3·min−1) were both significantly higher than for normal bone (K1 = 0.09 ± 0.03 mL·cm−3·min−1 and Ki = 0.05 ± 0.02 mL·cm−3·min−1, P < 0.001). Conclusion: Fluoride transport and flux can be accurately and independently estimated for bone metastases and normal vertebrae. Reasonable bias and precision for estimates of K1 and Ki from simulations and significant differences in values from patient modeling results in metastases and normal bone suggest that 18F-fluoride PET images may be useful for assessing changes in bone turnover in response to therapy. Future studies will examine the correlation of parameters to biologic features of bone metastases and to response to therapy.

【 授权许可】

Unknown