Innovations in Radiotherapy Planning of Head and Neck Cancers: Role of PET

Journal of Nuclear Medicine

Wim J.G. Oyen¹  Albert J. van der Kogel¹  Johannes H.A.M. Kaanders¹  Dominic A.X. Schinagl¹  Esther G.C. Troost¹  Johan Bussink¹  Otto C. Boerman¹ 

关键词: ¹⁸F-FDG PET;    head and neck carcinoma;    radiotherapy planning;    hypoxia;    proliferation;    radioresistance;   

DOI  :  10.2967/jnumed.108.061499

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Modern radiotherapy techniques heavily rely on high-quality medical imaging. PET provides biologic information about the tumor, complementary to anatomic imaging. Integrated PET/CT has found its way into the practice of radiation oncology, and 18F-FDG PET is being introduced for radiotherapy planning. The functional information possibly augments accurate delineation and treatment of the tumor and its extensions while reducing the dose to surrounding healthy tissues. In addition to 18F-FDG, other PET tracers are available for imaging specific biologic tumor characteristics determining radiation resistance. For head and neck cancer, the potential gains of PET are increasingly being recognized. This review describes the current role of PET and perspectives on its future use for selection and delineation of radiotherapy target volumes and for biologic characterization of this tumor entity. Furthermore, the potential role of PET for early response monitoring, treatment modification, and patient selection is addressed in this review.

【 授权许可】

Unknown