11C-Methionine PET of Acute Myocardial Infarction

Journal of Nuclear Medicine

Takuya Mitsumoto¹  Kimiteru Ito¹  Miyako Morooka¹  Michiaki Hiroe¹  Osamu Okazaki¹  Kazuo Kubota¹  Hiromu Kadowaki¹  Kuni Ohtomo¹  Ren Iwata¹  Mitsuo Kashida¹ 

关键词: ¹¹C-methionine;    myocardial infarction;    PET;    ¹⁸F-FDG;    remodeling;   

DOI  :  10.2967/jnumed.108.061341

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Tissue uptake of l-[methyl-11C]-methionine (11C-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether 11C-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and 201Tl SPECT, 18F-FDG PET, and 11C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The 11C-methionine images showed increased uptake in the infarcted area, whereas the 201Tl SPECT and 18F-FDG PET images showed decreased uptake. The highest accumulation of 11C-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: 11C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.

【 授权许可】

Unknown