Nuclear Imaging of Cancer Cell Therapies

Journal of Nuclear Medicine

Vladimir Ponomarev¹ 

[1] Department of Radiology, Memorial Sloan-Kettering Cancer Center Department of Radiology, Memorial Sloan-Kettering Cancer Center Department of Radiology, Memorial Sloan-Kettering Cancer Center

关键词: molecular imaging;    oncology;    PET/CT;    cell therapy;    reporter gene;   

DOI  :  10.2967/jnumed.109.064055

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

A promising role of cellular therapies in cancer treatment is reflected by the constantly growing number of clinical trials with adoptively transferred cells. Direct and indirect cell labeling for the nuclear imaging of transferred cells has been proven reliable for imaging adoptive cellular therapies. Both methods show their advantages and limitations. Direct labeling is a relatively easy, inexpensive, and well-established methodology. Indirect labeling using a reporter gene imaging paradigm allows for reliable, stable, and harmless visualization of cellular trafficking, persistence, proliferation, and function at the target site. It is expected that new human-derived reporter genes will be rapidly translated into clinical applications that require repetitive imaging for the effective monitoring of various genetic and cellular therapies.

【 授权许可】

Unknown