18F-FDOPA: A Multiple-Target Molecule

Journal of Nuclear Medicine

Pirjo Nuutila¹  Heikki Minn¹  Saila Kauhanen¹  Marko Seppänen¹ 

关键词: molecular imaging;    oncology;    neuroendocrine tumor;    insulinoma;    PET;    ¹⁸F-FDOPA;   

DOI  :  10.2967/jnumed.109.065664

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Although 6-18F-fluoro-l-dopa (18F-FDOPA) has been available to study the striatal dopaminergic system for more than 2 decades, the full potential of the tracer was not realized before the introduction of 18F-FDOPA PET and PET/CT to image a variety of neuroendocrine tumors (NETs) and pancreatic β-cell hyperplasia. Together with receptor-based imaging, 18F-FDOPA offers a formerly unforeseen means to assist in the management of NETs and infants with persistent hyperinsulinemic hyperplasia. Institutions with special expertise in surgical, oncologic, and radiologic therapeutic modalities for NETs derive the highest benefit from 18F-FDOPA PET/CT. 18F-FDOPA–guided therapy may add to NET control by ensuring maximal cytoreduction.

【 授权许可】

Unknown