Journal of Nuclear Medicine | |
18F-FMT Uptake Seen Within Primary Cancer on PET Helps Predict Outcome of Non–Small Cell Lung Cancer | |
Keigo Endo1  Kyoichi Kaira1  Tamotsu Ishizuka1  Noboru Oriuchi1  Noriko Yanagitani1  Noriaki Sunaga1  Yoshikatsu Kanai1  Hideyuki Tominaga1  Masatomo Mori1  Kimihiro Shimizu1  | |
关键词: 18F-α-methyltyrosine; positron emission tomography; 18F-fluorodeoxyglucose; lung cancer; prognostic factor; | |
DOI : 10.2967/jnumed.109.066837 | |
学科分类:医学(综合) | |
来源: Society of Nuclear Medicine | |
【 摘 要 】
L-[3-18F]-α-methyl tyrosine (18F-FMT) is an amino-acid tracer for PET imaging. We evaluated the prognostic significance of 18F-FMT PET in patients with non–small cell lung cancer. Methods: Ninety-eight patients (80 men and 18 women; age range, 42–82 y; median age, 69 y) with stage I–IV non–small cell lung cancer were enrolled in this study. They included 57 with adenocarcinoma, 31 with squamous cell carcinoma, 5 with large cell carcinoma, and 5 with other conditions. The median follow-up duration was 17.0 mo. A pair of PET studies with 18F-FMT and 18F-FDG was performed, and tracer uptake by the primary tumor was evaluated using the maximal standardized uptake value (SUVmax). Overall survival and disease-free survival were calculated by the Kaplan–Meier method. The prognostic significance was assessed by univariate and multivariate analyses. Results: The best discriminative SUVmax cutoffs for 18F-FMT and 18F-FDG in the primary tumors were 1.6 and 11, respectively. In the univariate analysis, a high SUVmax was significant in predicting poor overall survival for 18F-FMT (P = 0.0129) and 18F-FDG PET (P = 0.0481). According to histologic types, 18F-FMT and 18F-FDG uptake were a stronger prognostic predictor in adenocarcinoma than in nonadenocarcinomatous disease. Patients with a high SUVmax for 18F-FMT showed significantly worse disease-free survival rates than those with a low SUVmax, and multivariate analysis confirmed that a high SUVmax for 18F-FMT was an independent and significant factor in predicting a poor prognosis in patients with adenocarcinoma (P = 0.0191). Conclusion: Uptake of 18F-FMT in primary tumors was an independent prognostic factor in patients with pulmonary adenocarcinoma.
【 授权许可】
Unknown
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