Current and Potential Applications of Clinical 13C MR Spectroscopy

Journal of Nuclear Medicine

Robert Bok¹  Daniel B. Vigneron¹  John Kurhanewicz¹  Sarah J. Nelson¹ 

[1] University of California San Francisco San Francisco, California University of California San Francisco San Francisco, California University of California San Francisco San Francisco, California

关键词: molecular imaging;    MRI;    ¹³C;    magnetic resonance;    spectroscopy;   

DOI  :  10.2967/jnumed.107.045112

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

In this article, the current and potential clinical roles of 13C magnetic resonance spectroscopy (MRS) and 13C magnetic resonance spectroscopic imaging are presented, with a focus on applications to prostate cancer and hyperpolarized 13C spectroscopic imaging. The advantages of 13C MRS have been its chemical specificity and lack of background signal, with the major disadvantage being its inherently low sensitivity and the subsequent inability to acquire data at a high-enough spatial and temporal resolution to be routinely applicable in the clinic. The approaches to improving the sensitivity of 13C spectroscopy have been to perform proton decoupling and to use endogenous 13C-labeled or enhanced metabolic substrates. With these nominal increases in signal-to-noise ratio, 13C MRS using labeled metabolic substrates has shown diagnostic promise in patients and has been approved by the Food and Drug Administration. The development of technology that applies dynamic nuclear polarization to generate hyperpolarized 13C-labeled metabolic substrates, and the development of a process for delivering them into living subjects, have totally changed the clinical potential of MRS of 13C-labeled metabolic substrates. Preliminary preclinical studies in a model of prostate cancer have demonstrated the potential clinical utility of hyperpolarized 13C MRS.

【 授权许可】

Unknown