Journal of Nuclear Medicine | |
PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2 | |
Fangyu Peng1  Otto Muzik1  James Janisse1  Xin Lu1  Anthony F. Shields1  | |
关键词: prostate cancer; positron emission tomography; human copper transporter 1; copper (II)-64 chlorides; | |
DOI : | |
学科分类:医学(综合) | |
来源: Society of Nuclear Medicine | |
【 摘 要 】
Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. Results: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 ± 1.3 and 0.6 ± 0.3, respectively; P = 0.004), at 24 h after injection. Conclusion: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010196449ZK.pdf | 592KB | download |