PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2

Journal of Nuclear Medicine

Fangyu Peng¹  Otto Muzik¹  James Janisse¹  Xin Lu¹  Anthony F. Shields¹ 

关键词: prostate cancer;    positron emission tomography;    human copper transporter 1;    copper (II)-64 chlorides;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). Methods: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. Results: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 ± 1.3 and 0.6 ± 0.3, respectively; P = 0.004), at 24 h after injection. Conclusion: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.

【 授权许可】

Unknown