Comparison of Changes in Tumor Metabolic Activity and Tumor Size During Chemotherapy of Adenocarcinomas of the Esophagogastric Junction

Journal of Nuclear Medicine

Ambros J. Beer¹  Markus Schwaiger¹  Sibylle Ziegler¹  Ernst J. Rummeny¹  Wolfgang A. Weber¹  Florian Lordick¹  Hinrich A. Wieder¹  Katja Ott¹  Jörg R. Siewer¹  Michael Fischer¹ 

关键词: CT;    ¹⁸F-FDG PET;    esophageal cancer;    therapy monitoring;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We evaluated the temporal relationship between chemotherapy-induced changes in tumor glucose use and tumor size. Methods: Twenty patients with adenocarcinoma of the esophagogastric junction (AEG) were studied by 18F-FDG PET and CT scans before neoadjuvant chemotherapy, 14 d after the initiation of therapy, and 4 wk after the completion of therapy. Results: The relative change in 18F-FDG uptake was more than 2 times larger than the decrease in tumor size at all time points (P < 0.01). At 14 d after the initiation of chemotherapy, there was no correlation between the reduction in 18F-FDG uptake and tumor wall thickness. The change in 18F-FDG uptake after 14 d of therapy was significantly correlated with the reduction in tumor size after the completion of therapy. Conclusion: In AEG, changes in tumor metabolism are a more sensitive parameter for assessing the effects of chemotherapy than are changes in tumor size. Early changes in metabolic activity predict the subsequent reduction in tumor size.

【 授权许可】

Unknown