Journal of Nuclear Medicine | |
Comparison of Changes in Tumor Metabolic Activity and Tumor Size During Chemotherapy of Adenocarcinomas of the Esophagogastric Junction | |
Ambros J. Beer1  Markus Schwaiger1  Sibylle Ziegler1  Ernst J. Rummeny1  Wolfgang A. Weber1  Florian Lordick1  Hinrich A. Wieder1  Katja Ott1  Jörg R. Siewer1  Michael Fischer1  | |
关键词: CT; 18F-FDG PET; esophageal cancer; therapy monitoring; | |
DOI : | |
学科分类:医学(综合) | |
来源: Society of Nuclear Medicine | |
【 摘 要 】
We evaluated the temporal relationship between chemotherapy-induced changes in tumor glucose use and tumor size. Methods: Twenty patients with adenocarcinoma of the esophagogastric junction (AEG) were studied by 18F-FDG PET and CT scans before neoadjuvant chemotherapy, 14 d after the initiation of therapy, and 4 wk after the completion of therapy. Results: The relative change in 18F-FDG uptake was more than 2 times larger than the decrease in tumor size at all time points (P < 0.01). At 14 d after the initiation of chemotherapy, there was no correlation between the reduction in 18F-FDG uptake and tumor wall thickness. The change in 18F-FDG uptake after 14 d of therapy was significantly correlated with the reduction in tumor size after the completion of therapy. Conclusion: In AEG, changes in tumor metabolism are a more sensitive parameter for assessing the effects of chemotherapy than are changes in tumor size. Early changes in metabolic activity predict the subsequent reduction in tumor size.
【 授权许可】
Unknown
【 预 览 】
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RO201912010196162ZK.pdf | 737KB | download |