Enhancement of Radioiodine Treatment of Small-Pool Hyperthyroidism with Antithyroid Drugs: Kinetics and Dosimetry

Journal of Nuclear Medicine

Pat B. Zanzonico¹  David V. Becker¹  James R. Hurley¹ 

[1] Division of Nuclear Medicine, New York-Presbyterian Hospital, New York, New York; and Weill Medical College, Cornell University, New York, New York Division of Nuclear Medicine, New York-Presbyterian Hospital, New York, New York; and Weill Medical College, Cornell University, New York, New York Division of Nuclear Medicine, New York-Presbyterian Hospital, New York, New York; and Weill Medical College, Cornell University, New York, New York

关键词: thyroid;    hyperthyroidism;    radioiodine;    dosimetry;    antithyroid drugs;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

131I-Iodide is the treatment of choice in most cases of hyperthyroidism, with a standard 7,000-cGy (rad) thyroid absorbed dose generally resulting in an incidental blood absorbed dose of less than 10 cGy (rad). However, in ∼15% of patients there is a small, rapidly secreted thyroid iodine pool (small-pool patients) and, based on theoretic calculations, an incidental blood absorbed dose of up to 150 cGy (rad) could result. In such small-pool patients, continuing antithyroid drugs (ATDs) at a reduced dosage during 131I therapy should inhibit the formation of 131I-labeled levothyroxine and triiodothyronine and thereby reduce the protein-bound 131I-iodine concentration in blood and the blood absorbed dose. Methods: To test this hypothesis, thyroid and blood time–activity data were measured and absorbed doses were calculated for an 131I tracer administered to small-pool hyperthyroid patients (n = 9) not receiving ATDs (off ATDs) and then receiving ATDs (on ATDs). Results: The blood absorbed dose (cGy/37 MBq [rad/mCi] administered) was reduced from 2.54 ± 0.91 (mean ± SD) without ATDs to 1.27 ± 0.54 with ATDs (P < 0.0001), whereas the thyroid absorbed dose was unchanged (1,870 ± 700 vs. 2,080 ± 1,080). The blood absorbed dose for an administered 131I activity required to deliver a standard prescribed absorbed dose of 7,000 cGy (rad) to the thyroid therefore was reduced by over 50% with ATDs, from 11.3 ± 6.5 to 4.9 ± 2.8 cGy (rad) (P < 0.001). Conclusion: Continued administration of ATDs during 131I therapy thus can effectively reduce extrathyroid radiation in small-pool patients without significantly reducing the target tissue (i.e., thyroid) dose.

【 授权许可】

Unknown