Effects of Methylphenidate Discontinuation on Cerebral Blood Flow in Prepubescent Boys with Attention Deficit Hyperactivity Disorder

Journal of Nuclear Medicine

Hugh W. Ridlehuber¹  Glenn Austin¹  Daniel D. Langleben¹  Gary Krikorian¹  Igor Elman¹  Orith Portnoy¹  H. William Strauss¹  Paul D. Acton¹  John R. Monterosso¹ 

关键词: methylphenidate;    statistical parametric mapping;    SPECT;    attention deficit hyperactivity disorder;    motor cortex;    anterior cingulate cortex;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Methylphenidate (MPH) is an effective symptomatic treatment of attention deficit hyperactivity disorder (ADHD), but the mechanisms of its therapeutic action have not been fully elucidated. To address this issue, we assessed the effects of discontinuation of chronic MPH treatment on regional cerebral blood flow (rCBF) in ADHD patients. Methods: Twenty-two prepubescent boys with ADHD (age range, 8.2–11.5 y) and 7 healthy volunteers were studied with SPECT on and off MPH. Their rCBF data were automatically normalized to whole-brain counts and coregistered with standard anatomic space. rCBF changes were evaluated with statistical parametric mapping based on voxel-by-voxel ANOVA. Results: When the subjects were not taking MPH, rCBF was higher in the motor, premotor, and the anterior cingulate cortices (Brodmann’s areas 4, 6, and 32). Conclusion: Brief discontinuation of MPH treatment is associated with increased motor and anterior cingulate cortical activity. Our findings suggest that MPH treatment modulates motor and anterior cingulate cortical activity directly or indirectly. Alternatively, our findings may be related to MPH withdrawal. These data provide novel information on the potential mechanisms of the therapeutic action of MPH. Furthermore, they are clinically relevant to the commonly occurring brief interruptions in MPH treatment.

【 授权许可】

Unknown