Biodistribution of 99mTc-O4Na Changes in Adult Rats Whose Mothers Were Malnourished During Lactation

Journal of Nuclear Medicine

Magna Cottini Fonseca Passos¹  Mario Bernardo-Filho¹  Sheila C.P. Dutra¹  Egberto Gaspar Moura¹  Cristiane F. Ramos¹ 

关键词: protein restriction;    energy restriction;    lactation;    ^99mTc-O₄Na;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

99mTc-O4Na biodistribution changes in malnourished adults rats. We evaluated this biodistribution in rats whose mothers were malnourished during lactation. Methods: On the first day of lactation the mothers were separated into 3 groups: control (C) group, protein-restricted (PR) group, and energy-restricted (ER) group. After weaning all pups received a control diet until 60 d, when they were injected with 99mTc-O4Na and killed after 30 min. We evaluated the absolute percentage injected dose (%ID) and the %ID per gram (%ID/g) in thyroid, stomach, heart, bone, kidney, lung, liver, brain, and testes. Results: In the PR group, the %ID and %ID/g were significantly higher in the stomach and lower in the thyroid than in the C group. In the ER pups, the %ID and %ID/g were higher in the liver, stomach, and testes than in the C group. Conclusion: The mother’s nutritional status during lactation affects the biodistribution of 99mTc-O4Na in the offspring, and this condition must be considered when nuclear medicine examinations are indicated.

【 授权许可】

Unknown