Evaluation of Left Ventricular Function Using Electrocardiographically Gated Myocardial SPECT with 123I-Labeled Fatty Acid Analog

Journal of Nuclear Medicine

Haruo Hirayama¹  Akitada Ando¹  Makoto Nonokawa¹  Naoya Tsuboi¹  Makoto Hirai¹  Teruo Ito¹  Mitsuhiro Yokota¹  Satoshi Isobe¹  Hidehiko Saito¹  Mamoru Nanasato¹ 

[1] Cardiovascular Center, Nagoya Daini Red Cross Hospital, Nagoya; and First Department of Internal Medicine and Department of Clinical Laboratory Medicine, Nagoya University School of Medicine, Nagoya, Japan Cardiovascular Center, Nagoya Daini Red Cross Hospital, Nagoya; and First Department of Internal Medicine and Department of Clinical Laboratory Medicine, Nagoya University School of Medicine, Nagoya, Japan Cardiovascular Center, Nagoya Daini Red Cross Hospital, Nagoya; and First Department of Internal Medicine and Department of Clinical Laboratory Medicine, Nagoya University School of Medicine, Nagoya, Japan

关键词: gated SPECT;    β-methyl-p-¹²³I-iodophenylpentadecanoic acid;    ^99mTc-tetrofosmin;    left ventriculography;    left ventricular function;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Electrocardiographically (ECG) gated myocardial SPECT with 99mTc-tetrofosmin has been used widely to assess left ventricular (LV) function. However, the accuracy of variables using ECG gated myocardial SPECT with β-methyl-p-123I-iodophenylpentadecanoic acid (BMIPP) has not been well defined. Methods: Thirty-six patients (29 men, 7 women; mean age, 61.6 ± 15.6 y) with ischemic heart disease underwent ECG gated myocardial SPECT with 123I-BMIPP and with 99mTc-tetrofosmin and left ventriculography (LVG) within 1 wk. LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), and LV end-systolic volume (LVESV) were determined on gated SPECT using commercially available software for automatic data analysis. These volume-related items on LVG were calculated with an area–length method and were estimated by 2 independent observers to evaluate interobserver validity. The regional wall motion with these methods was assessed visually. Results: LVEF was 41.1% ± 12.5% on gated SPECT with 123I-BMIPP, 44.5% ± 13.1% on gated SPECT with 99mTc-tetrofosmin, and 46.0% ± 12.7% on LVG. Global LV function and regional wall motion between both gated SPECT procedures had excellent correlation (LVEF, r = 0.943; LVEDV, r = 0.934; LVESV, r = 0.952; regional wall motion, κ = 0.92). However, the correlations of global LV function and regional wall motion between each gated SPECT and LVG were significantly lower. Gated SPECT with 123I-BMIPP showed the same interobserver validity as gated SPECT with 99mTc-tetrofosmin. Conclusion: Gated SPECT with 123I-BMIPP provides high accuracy with regard to LV function and is sufficiently applicable for use in clinical SPECT. This technique can simultaneously reveal myocardial fatty acid metabolism and LV function, which may be useful to evaluate various cardiac diseases.

【 授权许可】

Unknown