Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT

Journal of Nuclear Medicine

Takahumi Ohta¹  Yukio Ishikawa¹  Atsutaka Okizaki¹  Chunlei Zhao¹  Naoyuki Hasebe¹  Junichi Sato¹  Wakako Yamamoto¹  Kenjiro Kikuchi¹  Noriyuki Shuke¹  Tamio Aburano¹ 

[1] Department of Radiology and First Department of Internal Medicine, Asahikawa Medical College; and Section of Radiology, Asahikawa Medical College Hospital, Asahikawa, Japan Department of Radiology and First Department of Internal Medicine, Asahikawa Medical College; and Section of Radiology, Asahikawa Medical College Hospital, Asahikawa, Japan Department of Radiology and First Department of Internal Medicine, Asahikawa Medical College; and Section of Radiology, Asahikawa Medical College Hospital, Asahikawa, Japan

关键词: hypertrophic cardiomyopathy;    dilated cardiomyopathy;    ¹²³I-metaiodobenzylguanidine;    ^99mTc-tetrofosmin;    gated myocardial SPECT;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The objective of this study was to clarify the relationship between cardiac sympathetic nervous function (CSNF) and left ventricular (LV) function and perfusion in hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Methods: Thirty-eight cases (32 males, 6 females; mean age, 56 ± 15 y), consisting of 5 healthy control subjects, 15 patients with DCM, and 18 patients with HCM, were studied with 123I-metaiodobenzylguanidine (MIBG) and 99mTc-tetrofosmin SPECT. CSNF was evaluated from cardiac uptake and washout of MIBG, whereas LV perfusion and function were evaluated from tetrofosmin uptake and wall thickening on electrocardiographically gated SPECT. As quantitative parameters of global cardiac MIBG uptake and washout, the heart-to-mediastinum ratio (H/M) and percentage washout were calculated from early and delayed planar images. As quantitative regional parameters, the regional uptake and percentage washout of MIBG were calculated from SPECT images dividing the left ventricle into 12 segments. In the tetrofosmin study, the H/M and LV ejection fraction were calculated as the parameters of global LV perfusion and function. As quantitative regional parameters, the regional uptake and wall thickening were also calculated for the 12 myocardial segments using the quantitative gated SPECT software. Multiple linear regression analysis was performed to investigate the correlations between the parameters from the 2 studies. Results: In DCM and HCM, multiple linear regression analysis of the regional parameters showed significant correlations between LV function and CSNF (P < 0.0001) and between LV perfusion and CSNF (P < 0.0001). According to the partial correlation coefficients, washout and early uptake of MIBG were the most significant factors for predicting LV function and LV perfusion, respectively. Conclusion: In cardiomyopathies, CSNF was closely related to LV function. The quantitative parameters of MIBG washout could reflect cardiac functional impairment. Early MIBG uptake might be determined by myocardial perfusion in cardiomyopathies.

【 授权许可】

Unknown