Microwave-assisted Synthesis of Benzo-[1,4]-oxazinones Using MeO-PEG-OMe as Solvent

Journal of the Korean Chemical Society

Gyunghee Gam¹  Kiwan Jang¹  Shin Hyuong Kim¹  Dong Soo Shin¹  Jae Min Lim¹ 

关键词: Pyrido-[1;    4]-oxazinone;    Smiles rearrangement;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Efficient one-pot microwave-assisted synthesis of various benzo-[1,4]-oxazinones via Smiles rearrangement is described. Treatment of 2-chloroacetamide, substituted 2-chlorophenols and cesium carbonate in MeO-PEG-OMe (2,000) as solvent afforded the corresponding benzo-[1,4]-oxazinones and 1H-pyrido[2,3-b][1,4]-oxazin-2-(3H)-one as moderate yield.

【 授权许可】

Unknown