Molecular Genetic Analysis of Behcets Disease in Korean

Journal of the Korean Chemical Society

Youn-Hyoung Nam¹  Young-Chang Ahn¹  Sang-Hyun Lee¹  Sang-Bum Park¹  Min-Ho Cho¹  Jong-Gyu Kim¹  Su-Min Park¹  Jae-Gu Choi¹  Seong-Kyu Kim¹  Won-Cheoul Jang¹ 

关键词: TNF-¥á;    BD (behcet¡¯s disease);    HLA-B51;    IL-18;    SLC11A1;    TNF-¥á;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Behcet¡¯s disease (BD) is a chronic inflammatory disorder, involving several organs. Inflammation in thedisease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. Although the exactpathogenesis for BD is not completely understood, it has been suggested that the disease is triggered in genetically susceptibleindividuals by environmental factors, such as microbial agents. It is noted that multiple genes, including MHC(major histocompatibility complex) and non-MHC genes, are implicated in the pathogenesis of BD. This study tries todetermine whether HLA-B51, IL-18, SLC11A1 and TNF-¥á polymorphisms are associated with susceptibility to Behcet'sdisease in Koreans. As a results, HLA-B51 was a genetic factor with the strongest association with BD. But it is stilluncertain whether this HLA molecule is directly involved in the pathogenesis of BD. Although the IL-18 gene polymorphismswere not associated with a susceptibility to BD in the Korean population, the patients carrying the GG genotypeat position 137 had a higher risk of developing the ocular lesions. This study suggests that the allele 3 and the genotype allele 3 / allele 3 of 5'-promoter (GT)n polymorphism in the SLC11A1 gene may have a protective effect forthe development of BD in the Korean population. There were no evidences for genetic association conferred by theTNF-¥á gene with respect to susceptibility to BD.

【 授权许可】

Unknown