Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals

Cancer Genomics - Proteomics

MARIA ANTONELLA ZINGAROPOLI³  VINCENZO VULLO³  CLAUDIO MARIA MASTROIANNI³  DONATELLA MARIA RODIO³  ALESSANDRA D'ABRAMO³  ANTONIO CIARDI⁴  MARCO IANNETTA³  MARIA ROSA CIARDI³  FRANCESCO IORI¹  FRANCESCA ANTONINI¹  ALESSANDRA OLIVA³  CESARE GIOVANNI FEDELE²  VALERIA ANTONIETTA PIETROPAOLO³  ELENA ANZIVINO³ 

[1] epartment of Obstretics, Gynecology and Urological Sciences, Sapienza University of Rome, Rome, Italyepartment of Obstretics, Gynecology and Urological Sciences, Sapienza University of Rome, Rome, Italyepartment of Obstretics, Gynecology and Urological Sciences, Sapienza University of Rome, Rome, Italy;iagnostic Microbiology Service National Center for Microbiology, Majadahonda, Madrid, Spainiagnostic Microbiology Service National Center for Microbiology, Majadahonda, Madrid, Spainiagnostic Microbiology Service National Center for Microbiology, Majadahonda, Madrid, Spain;epartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italyepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italyepartment of Health Sciences and Infectious Diseases, Sapienza University of Rome, Rome, Italy;epartment of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italyepartment of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italyepartment of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy

关键词: Polyomaviruses;    PyVs;    urothelial bladder carcinoma;    BKPyV;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: Polyomaviruses (PyVs) are potential transforming viruses. Despite their involvement in human tumours still being debated, there is evidence to suggest a role for PyVs in bladder carcinoma (BC). Therefore, a possible association between PyVs and BC was investigated. Materials and Methods: Urine, blood and fresh bladder tissue specimens were collected from 29 patients with BC. PyV prevalence, non-coding control region (NCCR) organization and genotypic analysis were assessed. Results: Data showed a significant prevalence of John Cunningham (JC) PyV in BC tissues and in urine with respect to BKPyV, while simian virus 40 was not revealed. A BKPyV rearranged NCCR sequence was isolated, whereas a JCPyV archetypal structure was consistently retained. A prevalence of European genotypes was observed. Conclusion: Our data would suggest a JCPyV involvement in cancer progression and a BKPyV association with BC pathogenesis in immunocompetent patients. However, further work is necessary to better understand the exact role of PyVs in urothelial carcinogenesis.

【 授权许可】

Unknown