Nodular cutaneous metastasis of the leg in advanced urothelial bladder carcinoma: a case report and systematic literature review

Frontiers in Oncology

Oncology

Paola Giancontieri¹  Silvia Lai²  Sara Izzo³  Luciano Izzo⁴  Raimondo Gabriele⁴  Giuliano D’Onghia⁴  Claudia De Intinis⁴  Paolo Izzo⁴  Maria Ludovica Costanzo⁴  Simone Sibio⁴  Andrea Polistena⁴ 

[1] Department of Radiological, Oncological and Anatomo-Pathological Sciences, Policlinico “Umberto I”, “Sapienza” University of Rome, Rome, Italy;Department of Translational and Precision Medicine, Nephrology Unit, Sapienza University of Rome, Rome, Italy;Multidisciplinary Department of Medical-Surgical and Dental Specialties, Plastic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Piazza Luigi Miraglia, Naples, Italy;“Pietro Valdoni” Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Rome, Italy;

关键词: bladder;    cancer;    metastasis;    urothelial;    cutaneous;    cutaneous metastasis;    urothelial bladder carcinoma;    systematic literature review;   

DOI  :  10.3389/fonc.2023.1216725

 received in 2023-05-24, accepted in 2023-08-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cutaneous metastases from urothelial carcinoma (UC) are very rare and indicate advanced disease with a poor prognosis. A 63-year-old female patient with a history of urothelial bladder carcinoma, treated 2 months prior with radical cystectomy and adjuvant gemcitabine and cisplatin (GC) therapy, presented a skin lesion localized in the lower third of the right leg. Punch biopsy revealed carcinomatous metastasis whose urothelial origin was confirmed by immunohistochemical analysis. 18-FDG PET-CT showed the spread of metastases to the lung and left ischium. Our review focuses on the time between surgery and skin metastasis, localization, and prognosis after metastasis diagnosis. In many cases, skin metastases occur within one year of initial UC surgery and in most cases occur on the abdominal wall. Local wide excision of metastasis should be considered in selected cases; however, chemotherapy remains the main treatment.

【 授权许可】

Unknown   
Copyright © 2023 Izzo, Izzo, Lai, D’Onghia, Giancontieri, Gabriele, Polistena, Sibio, Costanzo, De Intinis and Izzo