Current State of mTOR Targeting in Human Breast Cancer

Cancer Genomics - Proteomics

ANUP K. SHARMA³  WEN G. JIANG¹  ALI WAZIR²  UMAR WAZIR⁴  ZUBAIR S. KHANZADA¹  KEFAH MOKBEL⁴ 

[1] Cardiff University-Peking University Cancer Institute (CUPUCI), University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Cardiff, Wales, U.KCardiff University-Peking University Cancer Institute (CUPUCI), University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Cardiff, Wales, U.KCardiff University-Peking University Cancer Institute (CUPUCI), University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Cardiff, Wales, U.K;Aga Khan University, Karachi, PakistaAga Khan University, Karachi, PakistaAga Khan University, Karachi, Pakista;Department of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.KDepartment of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.KDepartment of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.K;The London Breast Institute, Princess Grace Hospital, London, U.KDepartment of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.KThe London Breast Institute, Princess Grace Hospital, London, U.KThe London Breast Institute, Princess Grace Hospital, London, U.KDepartment of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.KDepartment of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.KThe London Breast Institute, Princess Grace Hospital, London, U.KDepartment of Breast Surgery, St. George’s Hospital and Medical School, University of London, London, U.K

关键词: mTOR;    breast;    cancer;    rapamycin;    PIKK;    Rictor;    DAP1;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background/Aim: The mammalian, or mechanistic, target of rapamycin (mTOR) pathway has been implicated in several models of human oncogenesis. Research in the role of mTOR in human oncogenesis remains a field of intense activity. In this mini-review, we intend to recount our current understanding of the mTOR pathway, its interactions, and its role in human carcinogenesis in general, and breast cancer in particular. Materials and Methods: We herein outline the discrete components of the two complexes of mTOR, and attempt to define their distinct roles and interactions. Furthermore, we review current developments in the therapeutic targeting of mTOR in human breast cancer. Results: Our understanding of the organisation and interactions of the mTOR pathway continues to evolve. There has been significant incremental, albeit slow, progress in the therapeutic targeting of the mTOR pathway in human breast cancer. Conclusion: Continued progress in the field would require a better understanding of the role of the mTOR pathway in human breast cancer. By summarizing the current literature, this review will provide useful information on the topic.

【 授权许可】

Unknown