Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications

International Journal of Clinical and Experimental Pathology

Nina Tatevian¹  Sanda Alexandrescu¹  Oluyinka Olutoye¹  Robert E Brown¹ 

关键词: mTOR;    PHHI;    transdifferentiation;    rapamycin;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Amino-acids stimulate the mammalian target of rapamycin complex(mTORC)1; mTORC1 integrates amino-acid and energy-sensing pathways in beta-cells. Rapamycin inhibits mTORC1. We examined the mTOR pathway and cell cycle data in the exocrine pancreas in diffuse persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

【 授权许可】

Unknown