Brain-metastatic Triple-negative Breast Cancer Cells Regain Growth Ability by Altering Gene Expression Patterns

Cancer Genomics - Proteomics

JEONG-HYUN KIM³  YOUN KYUNG CHOI⁴  JIN WOOK KIM⁶  YEE JIN YUN⁴  SUNG-GOOK CHO⁴  DONG-YOUNG NOH²  HYOUNG DOO SHIN⁵  YONG CHOL SHIN⁴  HYO EUN MOON¹  SUN HA PAEK¹  SANG-MI WOO⁴  SEONG-GYU KO⁴  BO HYUNG JANG⁴ 

[1] Department of Neurosurgery, Ischemic/Hypoxia Disease InstituteCancer Research Institute, Ischemic/Hypoxia Disease InstituteDepartment of Neurosurgery, Ischemic/Hypoxia Disease InstituteDepartment of Neurosurgery, Ischemic/Hypoxia Disease InstituteCancer Research Institute, Ischemic/Hypoxia Disease InstituteCancer Research Institute, Ischemic/Hypoxia Disease InstituteDepartment of Neurosurgery, Ischemic/Hypoxia Disease InstituteCancer Research Institute, Ischemic/Hypoxia Disease Institute;Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Surgery, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea;Department of Life Science, Sogang University, Seoul, KoreaDepartment of Life Science, Sogang University, Seoul, KoreaDepartment of Life Science, Sogang University, Seoul, Korea;Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea;Department of Life Science, Sogang University, Seoul, KoreaDepartment of Genetic Epidemiology, SNP Genetics Inc., Seoul, Republic of KoreaDepartment of Life Science, Sogang University, Seoul, KoreaDepartment of Life Science, Sogang University, Seoul, KoreaDepartment of Genetic Epidemiology, SNP Genetics Inc., Seoul, Republic of KoreaDepartment of Genetic Epidemiology, SNP Genetics Inc., Seoul, Republic of KoreaDepartment of Life Science, Sogang University, Seoul, KoreaDepartment of Genetic Epidemiology, SNP Genetics Inc., Seoul, Republic of Korea;Department of Neurosurgery, Ischemic/Hypoxia Disease InstituteDepartment of Neurosurgery, Ischemic/Hypoxia Disease InstituteDepartment of Neurosurgery, Ischemic/Hypoxia Disease Institute

关键词: Triple-negative breast cancer;    brain metastasis;    PPL;    MAPK13;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Backgroud/Aim: Triple-negative breast cancer (TNBC) frequently metastasizes to the brain (BrM). However, genes responsible for BrM of TNBC are yet to be identified. Materials and Methods: Gene expression profiling of TNBC and BrM was conducted, and studies with cultured cells in vitro were performed to verify functions of genes identified in these analyses. Results: According to gene expression analyses of TNBC and BrM, periplakin (PPL) and mitogen-activated protein kinase 13 (MAPK13) were chosen for further investigations. PPL and MAPK13 were highly expressed in TNBC compared to BrM. While silencing of either PPL or MAPK13 in TNBC cells increased cell growth and reduced cell motility, overexpression of either PPL or MAPK13 in BrM cells, retarded growth rates and facilitated cell motility. Conclusion: Gene expression patterns in TNBC and BrM reflect cancer cell growth in regions of metastasis.

【 授权许可】

Unknown