Gene Expression Profiling of Circulating Natural Killer Cells in Head and Neck Squamous Cell Carcinoma

Cancer Genomics - Proteomics

ARNE BÖTTCHER³  RAINALD KNECHT³  DIRK KOCZAN²  BURKHARD KRAMP¹  JÜRGEN OSTWALD¹  STEFFEN DOMMERICH⁴ 

[1] Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, GermanDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, GermanDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, German;Institute of Immunology, University of Rostock, Rostock, GermanInstitute of Immunology, University of Rostock, Rostock, GermanInstitute of Immunology, University of Rostock, Rostock, German;Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, GermanDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, GermanDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, German;Department of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, GermanDepartment of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, GermanDepartment of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, German

关键词: Natural killer cells;    cytokine receptors;    gene expression;    HNSCC;    immune surveillance;    gene microarrays;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: Natural killer (NK) cells are a major player of the innate immune system. Besides known risk factors for head and neck squamous cell carcinoma (HNSCC), impaired immune surveillance may as well lead to tumor manifestation. Materials and Methods: In the present study, microarrays technologies were employed in order to perform gene expression profiling of NK cells in HNSCC patients. Differentially expressed genes have been detected in a comparative setting consisting of non-treated HNSCC patients, treated recurrence-free HNSCC patients and healthy control subjects. Results: Cytokine receptors such as CCR7, IL-7R, and CXCR3 were down-regulated in non-treated HNSCC patients compared to healthy subjects, indicating impaired immune surveillance. In treated patients, up-regulated genes such as receptors for Fc fragments of specific antibodies, or ficolin-1 can be withheld as an immunological response to tumor manifestation. Conclusion: This study provides insights into gene expression changes in NK cells of HNSCC dependent upon clinical status and introduces several candidate genes suitable for further investigation.

【 授权许可】

Unknown