A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk

Cancer Genomics - Proteomics

STEPHEN R. WEINSTEIN¹  LARISA HAUPT²  LYN R. GRIFFITHS²  PLAMENA N. GABROVSKA²  ROBERT A. SMITH²  DOMINIK J. JEDLINSKI³ 

[1] epartment of Pathology, Gold Coast Hospital, Southport, QLD, Australiaepartment of Pathology, Gold Coast Hospital, Southport, QLD, Australiaepartment of Pathology, Gold Coast Hospital, Southport, QLD, Australia;enomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australiaenomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australiaenomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia;enomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australiaepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerlandenomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australiaenomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australiaepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerlandepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerlandenomics Research Centre, Griffith Health Institute, Griffith University, Gold Coast, QLD, Australiaepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

关键词: MicroRNA;    breast cancer;    miR-423;    cancer risk;    SNP;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background/Aim: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A>C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. Materials and Methods: Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences. Results: Analysis indicated that there were significant differences between the case and control populations (χ2=6.70, p=0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio=0.50 95% confidence interval=0.27-0.92, p=0.03). Conclusion: Further functional research is required to determine the mechanism of action of this SNP on miRNA function.

【 授权许可】

Unknown