Tissue Microarray Analysis of Topoisomerase IIα Protein in Gastric Adenocarcinomas: Histogenetic and Prognostic Implications

Cancer Genomics - Proteomics

Jie Gao¹  Mengwei Wang²  Haili Huang²  Gangshi Wang²  Ping Chen³  Weidi You²  Benyan Wu² 

[1] Departments of Pathology, China PLA General Hospital, Beijing, P.R. ChinaDepartments of Pathology, China PLA General Hospital, Beijing, P.R. ChinaDepartments of Pathology, China PLA General Hospital, Beijing, P.R. China;Department of Geriatric Gastroenterology, China PLA General Hospital, Beijing, P.R. ChinaDepartment of Geriatric Gastroenterology, China PLA General Hospital, Beijing, P.R. ChinaDepartment of Geriatric Gastroenterology, China PLA General Hospital, Beijing, P.R. China;Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, U.S.A.Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, U.S.A.Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, U.S.A.

关键词: Gastric carcinoma;    topoisomerase IIα;    tissue microarray;    prognosis;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

The aim of this study was to: To investigate topoisomerase IIα (topo-IIα) expression and its correlation with clinicopathological parameters in primary gastric cancer patients. Patients and Methods: A tissue microarray including tumor, paired non-tumoral and lymph node metastasis specimens from 210 gastric adenocarcinoma patients was built for immunohistochemical interrogation. The correlation between topo-IIα expression and patient clinicopathological parameters was evaluated by univariate and multivariate analyses. Results: High topo-IIα expression was observed in 30.00% (63/210) of the primary tumors, 25.27% (23/91) of the lymph node metastases and 0.47% (1/210) of the non-tumoral gastric mucosa (p<0.001). Topo-IIα expression in the gastric adenocarcinoma was positively correlated with tumor location (gastric cardia, p<0.001), intestinal histological type (p=0.041), late age onset of gastric adenocarcinoma (≥50 years; p=0.002) and male gender (p=0.038). There was no association with other clinicopathological parameters. No correlation was observed between topo-IIα expression and survival. Conclusion: The prognostic value of topo-IIα in gastric adenocarcinoma remains underdetermined.

【 授权许可】

Unknown