Circadian Transcription Profile of Mouse Breast Cancer Under Light-Dark and Dark-Dark Conditions

Cancer Genomics - Proteomics

ALEX FRIEDMAN³  PATRICIA A. WOOD⁴  EUN-YOUNG OH⁴  JOVELYN DU-QUITON¹  CHRISTINE M. ANSELL¹  DINAH F. QUITON¹  WILLIAM J.M. HRUSHESKY²  XIAOMING YANG¹ 

[1] Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.;Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.School of Public Health, University of South Carolina Columbia, SC 29209, U.S.A.School of Engineering and Computer Science, University of South Carolina Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.School of Public Health, University of South Carolina Columbia, SC 29209, U.S.A.School of Engineering and Computer Science, University of South Carolina Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.School of Public Health, University of South Carolina Columbia, SC 29209, U.S.A.School of Engineering and Computer Science, University of South Carolina Columbia, SC 29209, U.S.A.School of Public Health, University of South Carolina Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.School of Public Health, University of South Carolina Columbia, SC 29209, U.S.A.School of Engineering and Computer Science, University of South Carolina Columbia, SC 29209, U.S.A.School of Engineering and Computer Science, University of South Carolina Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.School of Public Health, University of South Carolina Columbia, SC 29209, U.S.A.School of Engineering and Computer Science, University of South Carolina Columbia, SC 29209, U.S.A.;Washington University, St. Louis, MO 63130 U.S.A.Washington University, St. Louis, MO 63130 U.S.A.Washington University, St. Louis, MO 63130 U.S.A.;Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.Medical Chronobiology Laboratory, Dorn Research Institute, WJB Dorn VA Medical Center, Columbia, SC 29209, U.S.A.School of Medicine, University of South Carolina Columbia, SC 29209, U.S.A.

关键词: Circadian;    microarray;    breast cancer;    gene expression;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

The circadian clock exists in virtually every cell and regulates key biological processes in cells and tissues. Even in cancer cells, DNA synthesis, cell division and tumor growth are gated by the circadian clock. This study examined the gene expression profiles of transplanted mouse breast tumor cells under normal light-dark (LD) as well as constant dark (DD) conditions. It was found that the overall percentage of rhythmic transcripts in breast tumor tissue was lower than that in normal tissue. Few transcripts had unaltered rhythmic expression patterns under both LD and DD conditions. Most rhythmic transcripts in DD displayed 12h or shorter periods. These results suggest that in addition to the circadian clock control of gene transcription, altering light, feeding, physical activity and other factors characteristically affect the expression of many genes.

【 授权许可】

Unknown