The Role of Folate Metabolism-related Gene Polymorphisms in the Development of Meningiomas

Cancer Genomics - Proteomics

STEFANOS S. DRAKOS¹  CHARIS LIAPI¹  FOTEINI ANIFANTAKI¹  APOSTOLOS ZARROS¹ 

[1] Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

关键词: Meningiomas;    folate metabolism;    gene polymorphisms;    methylenetetrahydrofolate reductase;    methionine synthase;    methionine synthase reductase;    thymidylate synthase;    reduced folate carrier;    cystathione-β-synthase;    review;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Meningiomas are (usually) slow-growing benign tumors, and several factors have been implicated in their development. Increasing age, previous exposure to ionizing radiation, endogenous hormone status and history, hormone replacement therapy, genetic variants and polymorphisms are the main factors that have been proven or assumed to be involved in meningioma formation. The complex genetic background supporting the pathogenesis of meningiomas includes a large number of mutations and polymorphisms that might be actively involved in tumor development, progression and recurrence. The aim of this mini-review is to summarize the current data concerning the role of folate metabolism-related gene polymorphisms in the development of meningiomas.

【 授权许可】

Unknown