An innovative radio-guided surgery technique for complete resection of tumors

5th Young Researcher Meeting, Trieste 2014

Russomando, A.^1,2,3 ; Collamati, F.^1,2 ; Bellini, F.^1,2 ; Bocci, V.^2 ; De Lucia, E.^4 ; Faccini, R.^1,2 ; Frallicciardi, P.M.^2,5 ; Marafini, M.^2,5 ; Mattei, I.^2,6 ; Morganti, S.^2 ; Patera, V.^2,7 ; Piersanti, L.^2,7 ; Pinci, D.^2 ; Recchia, L.^2 ; Senzacqua, M.^1,2 ; Sarti, A.^4,7 ; Sciubba, A.^2,7 ; Solfaroli Camillocci, E.^3 ; Voena, C.^1,2

Dipartimento di Fisica, La Sapienza Università di Roma, Rome, Italy^1

INFN Sezione di Roma, Rome, Italy^2

Center for Life Nano Science at Sapienza, Istituto Italiano di Tecnologia, Rome, Italy^3

Laboratori Nazionali di Frascati dell'Infn, Frascati, Italy^4

Museo Storico della Fisica e Centro Studi e Ricerche E. Fermi, Rome, Italy^5

Dipartimento di Fisica, Università RomaTre, Rome, Italy^6

Dipartimento di Scienze di Base e Applicate per l'Ingegneria, La Sapienza Università di Roma, Rome, Italy^7

关键词: Diffuse background;    Guided surgery;    High penetrations;    Life expectancies;    Meningiomas;    Photon efficiency;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/566/1/012020/pdf
DOI  :  10.1088/1742-6596/566/1/012020

来源: IOP

【 摘 要 】

Finding new ways to fight cancer is essential to increase the patients life expectancy. This paper reports the latest results of the project CHIRONE finalized to increase the potential of the Radio Guided Surgery through the use of β-emitting radio-tracers and β-probes. This innovation could overcome the present main limiting factor represented by a diffuse background due to the high penetration power of the gamma radiation used. We created a prototype of β-probe and in this paper we report measures of photon efficiency, acquired with commercial photons sources. Then we estimated the signal and background rates in realistic cases of meningioma through a simulation. The device is able to detect residuals of 0.1 ml in 1 s with an administered activity less than 3 MBq/kg.